Ah receptor at the crossroads between drug metabolism and barrier
Programme of the Session
AHR as a link for "environment - immunity - barrier"
IUF - Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
Putative role of the Ah receptor as a sensor for microbial secondary metabolites
Dieter Schrenk, Julia Alice Fuhlbrück, Ruth Schulte-Hubbert
Food Chemistry and Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
TIPARP and ADP-ribosylation negatively regulate AHR activity
Department of Nutrition, University of Oslo, Oslo, Norway
AhR-deficiency as a cause of demyelinating diseases and inflammation
Ludmila Juricek1, Julie Carcaud2, Alice Pelhaitre1, Thorfinn Riday3, Aline Chevallier1, Justine Lanzini4, Nicolas Auzeil4, Olivier Laprévote4, Florent Dumont5, Sébastien Jacques5, Frank Letourneur5, Charbel Massaad1, Cendra Agulhon3, Robert Barouki1, Mathieu Beraneck2, Xavier Coumoul1
1University Paris Descartes, Inserm Umr-S 1124, Paris, France; 2University Paris Descartes, CNRS Umr 8119, Paris, France; 3University Paris Descartes, CNRS FR 3636, Paris, France; 4University Paris Descartes, CNRS Umr 8638, Paris, France; 5University Paris Descartes, Plateforme Sequencage Genomique, Paris, France
The AHR as a Therapeutic Target for Inflammatory Skin Diseases
Ellen van den Bogaard
Dermatology, Radboud University Medical Center, Nijmegen, Netherlands
The aryl hydrocarbon receptor (AhR) was originally considered to function primarily as a sensor for polycyclic aromatic hydrocarbons, polyhalogenated dibenzo-p-dioxins or dibenzofurans. Its close links to the induction of drug metabolizing enzymes suggested that AhR activation is mainly aimed at metabolic elimination of all kinds of inducing environmental pollutants and dietary chemicals by inducing phase I and II metabolism primarily in the liver. Meanwhile, it has become well established that the AhR can act as a sensor for endogenous and exogenous modulators of the immune response, i.e., by influencing the differentiation of naïve T lymphocytes. This function is probably of eminent importance for a proper control of (auto-)immune responses and an adapted defence towards exogenous factors at barriers of the organism. The various implications of this multi-facetted function of AhR in immune surveillance, feedback control of immune function, and its consequences for the whole organism will be discussed, including novel mechanisms controlling the receptor action in various tissues. These new exciting discoveries provide a novel perspective for the biological role of the AhR, which has been originally studied only as a sensor of toxicants, but which has been now implicated in a wide range of human conditions, including autoimmune and allergic disorders, or regulation of organism response towards microorganisms or tumorigenesis. The proposed session would thus provide a unique opportunity for discussing these novel findings with prominent experts in the field, combining both toxicology and biomedical research.