Challenges for validation of predictive biomarkers for both toxicology and ecotoxicology
Programme of the Session
- Role of the adverse outcome pathway (AOP) framework in the validation of predictive biomarkers
US Environmental Protection Agency, Office of Research and Development, Mid-Continent Ecology Division, Duluth, United States
- Biomarkers in invertebrate species: addressing environmental, physiological and phylogenetic variability for a reliable monitoring of freshwater ecosystem contamination
Olivier Geffard, Arnaud Chaumot
Ecotoxicology, Irstea, Villeurbanne, France
The idea of the workshop is to share expertise and practices between toxicology and ecotoxicology for the validation of predictive biomarkers. The idea is to go further classical regulatory requirements in order to ensure that a defined biomarker is biologically plausible, that there is a threshold between a normal status and adverse effect at different scales (from molecule to population), that short as well as long-term effects are related to the temporality of the exposure during life time, that genomic, epigenomic and phenotypic status of an organism or a population and related effects is taken into account during the exposure leading to an adverse effect.
The work shop aims to propose “good practices” in biomarker designed in order to fulfil the different criteria that make it biologically plausible beyond regulatory requirements.