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Session 21

Oxidatively Damaged Nucleic Acids – Analyses and Roles in Disease

Programme of the Session

  • S21-01
    Measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine by an improved ELISA 

    Pavel Rossner Jr.1, Hilmi Orhan2, Gudrun Koppen3, Kazuo Sakai4, Regina M. Santella5, Antonin Ambroz1, Andrea Rossnerova1, Radim J. Sram1, Miroslav Ciganek6, Jiri Neca6, Ege Arzuk2, Neliye Mutlu2, Marcus S. Cooke
    1Institute of Experimental Medicine AS CR, Prague, Czech Republic; 2Ege University, Faculty of Pharmacy, Bornova-Izmir, Turkey; 3Flemish Institute for Technological Research, Antwerp, Belgium; 4Japan Institute for the Control of Aging, Shizuoka, Japan; 5Columbia University, New York, United States; 6Veterinary Research Institute, Brno, Czech Republic; 7Florida International University, Miami, United States
  • S21-02
    Oxidative stress and feto-maternal well-being in pregnancy 

    Marcus Cooke1, Justin Konje2, Neelam Potdar
    1Environmental and Occupational Health, Florida International University, Miami, United States; 2University of Leicester, Leicester, United Kingdom
  • S21-03
    Oxidative DNA damage in cancer patients: Associations between persistent organic pollutants and biomarkers of cellular targets

    Hilmi Orhan 
    Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, Bornova/İzmir, Turkey
  • S21-04
    The response to oxidative stress: a gene-environment interaction 

    Eugenia Dogliotti 
    Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy

Session Abstract

Oxidative stress as an inevitable process affecting all organisms is caused both by endogenous and exogenous factors. Although the organisms possess various antioxidant and repair systems, some oxidatively damaged macromolecules may persist and contribute to pathological processes. The study of oxidatively generated damage to DNA and RNA is critical, as it may lead to adverse health effects at both individual and generational levels (e.g. cancer, aging, cardiovascular and neurodegenerative diseases). Although there are several analytical methods available for measurement of the well-established 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) in biological samples (cells, tissues and extracellular matrices), the accuracy and specificity, as well as consistency between various techniques (ELISA, HPLC-MS/MS and HPLC with electrochemical detection) has been questionable. Considerable progress to overcome this problem has been made over the last decade. This technical issue will be addressed in the symposium. The speakers will further concentrate on the role of oxidatively damaged nucleic acids in health as well as in human diseases, in terms of different pathologies, and chemical exposures. Apart from oxidative damage to DNA, also an emerging field of processes associated with RNA oxidation will be covered. The symposium will bring together leading scientists who devoted most of their careers to studies of oxidative stress. 
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