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Session 19

Ah receptor at the crossroads between drug metabolism and barrier

Programme of the Session

  • AHR as a link for "environment - immunity - barrier" 
    Charlotte Esser
    IUF - Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany
  • Putative role of the Ah receptor as a sensor for microbial secondary metabolites 
    Dieter Schrenk, Julia Alice Fuhlbrück, Ruth Schulte-Hubbert 
    Food Chemistry and Toxicology, University of Kaiserslautern, Kaiserslautern, Germany
  • TIPARP and ADP-ribosylation negatively regulate AHR activity 
    Jason Matthews 
    Department of Nutrition, University of Oslo, Oslo, Norway
  • AhR-deficiency as a cause of demyelinating diseases and inflammation 
    Ludmila Juricek1, Julie Carcaud2, Alice Pelhaitre1, Thorfinn Riday3, Aline Chevallier1, Justine Lanzini4, Nicolas Auzeil4, Olivier Laprévote4, Florent Dumont5, Sébastien Jacques5, Frank Letourneur5, Charbel Massaad1, Cendra Agulhon3, Robert Barouki1, Mathieu Beraneck2, Xavier Coumoul
    1University Paris Descartes, Inserm Umr-S 1124, Paris, France; 2University Paris Descartes, CNRS Umr 8119, Paris, France; 3University Paris Descartes, CNRS FR 3636, Paris, France; 4University Paris Descartes, CNRS Umr 8638, Paris, France; 5University Paris Descartes, Plateforme Sequencage Genomique, Paris, France
  • The AHR as a Therapeutic Target for Inflammatory Skin Diseases
    Ellen van den Bogaard
    Dermatology, Radboud University Medical Center, Nijmegen, Netherlands

Session Abstract

The aryl hydrocarbon receptor (AhR) was originally considered to function primarily as a sensor for polycyclic aromatic hydrocarbons, polyhalogenated dibenzo-p-dioxins or dibenzofurans. Its close links to the induction of drug metabolizing enzymes suggested that AhR activation is mainly aimed at metabolic elimination of all kinds of inducing environmental pollutants and dietary chemicals by inducing phase I and II metabolism primarily in the liver. Meanwhile, it has become well established that the AhR can act as a sensor for endogenous and exogenous modulators of the immune response, i.e., by influencing the differentiation of naïve T lymphocytes. This function is probably of eminent importance for a proper control of (auto-)immune responses and an adapted defence towards exogenous factors at barriers of the organism. The various implications of this multi-facetted function of AhR in immune surveillance, feedback control of immune function, and its consequences for the whole organism will be discussed, including novel mechanisms controlling the receptor action in various tissues. These new exciting discoveries provide a novel perspective for the biological role of the AhR, which has been originally studied only as a sensor of toxicants, but which has been now implicated in a wide range of human conditions, including autoimmune and allergic disorders, or regulation of organism response towards microorganisms or tumorigenesis. The proposed session would thus provide a unique opportunity for discussing these novel findings with prominent experts in the field, combining both toxicology and biomedical research.    

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