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Session 14

Complex environmental mixtures - a challenge for understanding the mechanism of toxic action of PAHs

Programme of the Session

  • Metabolic Activation of Petrogenic Polycyclic Aromatic Hydrocarbons (PPAH): Potential Biomarkers for Human Exposure to Oil Spills 
    Trevor Penning1, Meng Huang1, Clementina Mesaros1, Ian Blair1, Sharon Croisant2, Cornelis Elferink
    1Center of Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, United States; 2Center for Environmental Toxicology, University of Texas Medical Branch, Galveston, United States
  • Mechanisms of toxicity of particulate engine emissions from diesel and alternative fuels under realistic traffic conditions 
    Jan Topinka1, Michal Vojtisek-Lom2, Jiri Klema3, Miroslav Machala4, Helena Libalova
    1Department of Genetic Toxicology and Nanotoxicology, Institute of Experimental Medicine CAS, Prague, Czech Republic; 2Center of Vehicles for Sustainable Mobility, Czech Technical University in Prague, Prague, Czech Republic; 3Department of Cybernetics, Czech Technical University in Prague, Prague, Czech Republic; 4Department of Chemistry and Toxicology, Veterinary Research Institute, Brno, Czech Republic
  • Interference of polycyclic aromatic hydrocarbons and their complex mixtures with steroid signaling 
    Jan Vondracek1, Martina Hyzdalova1, 2, Jakub Pivnicka1, 3, Ondrej Zapletal1, 3, Gerardo Vazquez-Gomez1, Jason Matthews4,  Jiri Neca2, Miroslav Machala
    1Institute of Biophysics of the CAS, Brno, Czech Republic; 2Veterinary Research Institute, Brno, Czech Republic; 3Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic; 4University of Oslo, Oslo, Norway
  • The genome as a record for environmental exposure to polycyclic aromatic hydrocarbons 
    Volker M. Arlt1, Jill E. Kucab1, Madeleine Joel1, Serena Nik-Zainal2, Michael R. Stratton2, David H. Phillips1
    1Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom; 2Wellcome Trust Genome Campus, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
  • The Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons in the Transgenic Rodent Muta™Mouse 
    Alexandra Long1, Christine Lemieux1, Volker Arlt2, Iain Lambert3, Paul White
    1Health Canada, Ottawa, Canada; 2King's College London, London, United Kingdom

Session Abstract

Humans are rarely environmentally exposed to single toxic substances but more commonly to complex mixtures. In order to evaluate the health risks posed by these chemicals understanding their mode of action is critical for accurate risk assessment. It is only modes and mechanisms that can assign causation of adverse outcomes from chemical exposure. Given the great interest in the human health hazards/risks of complex mixtures of combustion-derived mutagenic carcinogens the workshop will focus on the mechanisms of (geno)toxicity of polycyclic aromatic hydrocarbons (PAHs). The session will provide a forum to present current approaches for human health risk assessment and management of complex PAH mixtures including those by international regulatory authorities. The workshop will provide an opportunity for critical evaluation of risk assessment methods and approaches; and moreover, the development of an agenda to develop and deploy novel methods for the assessment and management of hazards/risks posed by complex mixtures of combustions-derived mutagenic carcinogens (i.e. PAHs) such as those present in vehicular exhausts and urban air. The session will also focus on the underlying mechanisms of PAH carcinogenesis and host factors (e.g. metabolism, inflammation, endocrine disruption) that are involved in mediating adverse toxic and/or carcinogenic responses of PAHs in exposed individuals. The session brings together world-leading experts in genetic, molecular & environmental toxicology and cancer biology. 
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