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Session 10

Lipids and membranes as targets of chemical toxicants

Programme of the Session

  • Gangliosides and glycosphingolipid metabolism as regulators of cell membrane organization and functions: the link between membrane perturbation and pathological conditions 
    Alessandro Prinetti 
    Medical Biotechnology and Translational Medicine, University of Milano, Milano, Italy
  • Polychlorinated biphenyls as modulators of sphingolipid and prostaglandin metabolism, intercellular communication and cell adhesion 
    Miroslav Machala1, Josef Slavik1, Katerina Pencikova1, Jiri Neca1, Pavlina Simeckova1, Pavel Kulich1, Jan Vondracek
    1Department of Chemistry and Toxicology, Veterinary Research Institute, Brno, Czech Republic; 2Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic
  • The focal adhesion point and cell migration – a new target of the AhR 
    Céline Tomkiewicz, Laurence Herry, Linh-Chi Bui, Robert Barouki, Xavier Coumoul 
    INSERM UMR-S 1124, University Paris Descartes, PARIS, France
  • Membrane remodeling by polycyclic aromatic hydrocarbons and its role in cell death signalling 
    Dominique Lagadic-Gossmann 
    IRSET, UMR Inserm 1085 - Université Rennes 1, Rennes, France
  • Cytotoxicity of environmental pollutants and implications in atherosclerosis 
    Bernhard Hennig, Michael Petriello 
    University of Kentucky Superfund Research Center, University of Kentucky, Lexington, United States

Session Abstract

Effects of chemical toxicants on cellular membranes, cell-cell communication and intracellular lipid signalling are a novel, rapidly emerging field in toxicology. The main aim of the proposed workshop is to provide the meeting audience with up-to-date presentations suggesting that various types of organic pollutants, including the ligands of the aryl hydrocarbon receptor, can alter plasma membrane structure and function, as well as modulate both intercellular and intracellular signalling modules. Such toxic events have been shown to modulate cell adhesion, migration and invasion capacity, as well as cell death, processes linked to tumour promotion and progression or atherosclerosis. This rapidly developing field of molecular toxicology should be covered in the form of the proposed workshop. The first lecture will be devoted to a general overview of sphingolipid metabolism and a link between membrane damage/remodelling and the relevant clinical/pathological conditions. The rest of the proposed session is then devoted to the impact of several major groups of organic pollutants, including polycyclic aromatic hydrocarbons and polychlorinated biphenyls, on toxic endpoints relevant for membrane-linked toxic effects.  
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