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Clinical Toxicology: New insights in the mechanisms of toxicity mediated by metabolic pathways

Programme of the Session

10:00 – 10:15 CE course opening and introduction
10:15 – 10:55 Drug-induced liver injury: role of obesity and nonalcoholic fatty liver disease 
Bernard Fromenty
INSERM, U991, Rennes-1 University, France
10:55 – 11:35 Mechanisms of drug-induced lactic versus non-lactic endogenous acidosis  
Bruno Mégarbane 
Lariboisière Hospital, Paris-Diderot University, France
11:35 – 12:00 Discussion
12:00 – 13:00 Lunch
13:00 – 13:40 Mechanisms of drug-induced hyperamonemia
Florian Eyer
Department of Toxicology, Klinikum rechts der Isar, Germany
13:40 – 14:20 Mechanisms of drug-induced methemoglobinemia  
Sally Bradberry
Director of Poison Center West Midlands Poisons Unit, City Hospital
14:20 – 15:00

Mechanisms of glycol-induced renal toxicity (including ethylene and di-ethylene glycol)  
Ken McMartin 
Louisiana State University Health Sciences Center - Shreveport Louisiana, USA

15:00 – 15:40 

Contribution of solvents in pesticide toxicity    
Michael Eddleston
NPIS Edinburgh, Royal Infirmary, UK

15:40 – 16:00 Discussion and Closing of the CE course

Session Abstract

Investigating the mechanisms of toxicity in humans is helpful to understand the patterns and variability of presentations and to improve patient management. This Continuing Education Course aims to present the new insights in mechanisms of toxicity resulting from metabolic pathways as well as their relevance to clinical toxicology. Several metabolic impairments will be considered like non-lactic endogenous acidosis, hyperamonemia, methemoglobinemia, acute renal failure and liver injury. Recently published experimental data on acetaminophen, glycol and pesticide poisoning with high relevance to clinical toxicology will be presented.

14:20 – 15:00 



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