Stem Cells and Their Applications in Toxicology
Programme of the Session
Stem cells in toxicity testing: where are we today?
Joery De Kock
In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium
A novel three-dimensional model for long-term evaluation of drug toxicity in vitro
Hassan Rashidi1,2, David Hay1
1MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom; 2Institute of Hepatology, London, United Kingdom
A novel bifunctional, hybrid bioelectronic real time High Content Screening platform for hESC and hiPSC derived cardiomyocytes
Molecular biological-biochemical Processing Technology, Leipzig University, Centre for Biotechnology and Biomedicine, Leipzig, Germany
Single-donor iPS cell derived multi-organ-chips to address individualized systemic toxicity
Anja Ramme, Eva Dehne, Reyk Horland, Uwe Marx
TissUse, Berlin, Germany
Investigating neurotoxicity using pluripotent stem cells
Pathology and Immunology, Geneva Medical Faculty and University Hospitals, Geneva, Switzerland
Stem cells are a source of self-renewable cells that hold great promise for both regenerative and toxicological applications due to their cellular plasticity and large expandability. Moreover, they can be obtained from human tissue and are able to develop into all kinds of target cells upon specific stimulation with intra and/or extracellular signals. These human stem cell-derived target cells can be used to test new chemical entities for their potential adverse effects towards man and therefore play a critical role in the drug development process. Within this session, key players will talk about their recent advancements that have been made using stem cell-derived target cells to predict organ-specific toxicity including cardiotoxicity, hepatotoxicity and neurotoxicity and the development of stem cell-based multi-organ in vitro systems.