Session 22

Long-Term (Inhalation) Toxicity of Poorly Soluble Nano Materials

Programme of the Session

S22-01
Long-term inhalation study with CeO₂- and BaSO₄ nanomaterials – study design, in-life findings, and lung burden
Lan Ma-Hock¹, Sibylle Groeters¹, Volker Strauss¹, Jana Keller¹, Karin Wiench², Bennard van Ravenzwaay¹, Robert Landsiedel¹
¹Experimental Toxicology and Ecology, BASF SE, Ludwigshafen/Rhein, Germany; ²Product Safety, BASF SE, Ludwigshafen/Rhein, Germany
S22-02
Long-term inhalation study with CeO₂- and BaSO₄-nanomaterials – histopathology of the lung
Heinrich Ernst¹, Susanne Rittinghausen¹, Dirk Schaudien¹, Sibylle Gröters², Lan Ma-Hock², Jana Keller², Petra Apel³, Robert Landsiedel²
¹Department of Pathology, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany; ²Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany; ³German Environment Agency (UBA), Berlin, Germany
S22-03
Biokinetics of engineered nanoparticles (NPs)
Joseph Brain¹, Ramon Molina¹, Nagarjun Konduru¹, Wendel Wohlleben²
¹Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, United States; ²BASF SE, Ludwigshafen, Germany
S22-04
Long-Term Toxicity Carbon Nanotubes: Commonality and Differences
Craig Poland, Rodger Duffin, Fiona Murphy
Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
S22-05
Genotoxicity of engineered nanoparticles
Maria Dusinska, Naouale El Yamani, Elisabeth Elje, Elise Rundén-Pran
Health Effects Laboratory, Department of Environmental Chemistry, NILU-Norwegian Institute for Air Research, Kjeller, Norway

Session Abstract

Many nanomaterials belong to the group of materials of poorly soluble biopersistent particles. Up to now only two of these nanomaterials, titanium dioxide and carbon black, have been tested in long-term rat inhalation studies. Chronic inhalation of those particles resulted in lung tumors in rats. These lung tumors were only observed at high concentrations, which also lead to an overload of the lung clearance and also caused inflammations of the lung. Meanwhile a new and unique long-term carcinogenicity studies (24 months according to OECD guideline, and an additional group with life-time (28 months) observation) have been performed with Ceroxide and Barium. The concentrations chosen covered the range around and above the occupational exposure concentrations. Potential concentration-effect relationship can be made. Moreover, long-term inhalation toxicity data about carbon nanotubes are available. The workshop will give an overview of the most recent data on carcinogenicity of inhaled poorly soluble nanomaterials, as well as potential underlying mechanism for the effects. The session will also deal with potential genotoxicity and the kinetics of these nano materials.