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Session 22

Long-Term (Inhalation) Toxicity of Poorly Soluble Nano Materials

Programme of the Session

  • Long-term inhalation study with CeO2- and BaSO4 nanomaterials – study design, in-life findings, and lung burden 
    Lan Ma-Hock1, Sibylle Groeters1, Volker Strauss1, Jana Keller1, Karin Wiench2, Bennard van Ravenzwaay1, Robert Landsiedel
    1Experimental Toxicology and Ecology, BASF SE, Ludwigshafen/Rhein, Germany; 2Product Safety, BASF SE, Ludwigshafen/Rhein, Germany
  • Long-term inhalation study with CeO2- and BaSO4-nanomaterials – histopathology of the lung 
    Heinrich Ernst1, Susanne Rittinghausen1, Dirk Schaudien1, Sibylle Gröters2, Lan Ma-Hock2, Jana Keller2, Petra Apel3, Robert Landsiedel
    1Department of Pathology, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany; 2Department of Experimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany; 3German Environment Agency (UBA), Berlin, Germany
  • Biokinetics of engineered nanoparticles (NPs)

    Joseph Brain1, Ramon Molina1, Nagarjun Konduru1, Wendel Wohlleben2
    1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, United States; 2BASF SE, Ludwigshafen, Germany

  • Long-Term Toxicity Carbon Nanotubes: Commonality and Differences 
    Craig Poland, Rodger Duffin, Fiona Murphy 
    Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom

  • Genotoxicity of engineered nanoparticles
    Maria Dusinska, Naouale El Yamani, Elisabeth Elje, Elise Rundén-Pran
    Health Effects Laboratory, Department of Environmental Chemistry, NILU-Norwegian Institute for Air Research, Kjeller, Norway

 

Session Abstract

Many nanomaterials belong to the group of materials of poorly soluble biopersistent particles. Up to now only two of these nanomaterials, titanium dioxide and carbon black, have been tested in long-term rat inhalation studies. Chronic inhalation of those particles resulted in lung tumors in rats. These lung tumors were only observed at high concentrations, which also lead to an overload of the lung clearance and also caused inflammations of the lung. Meanwhile a new and unique long-term carcinogenicity studies (24 months according to OECD guideline, and an additional group with life-time (28 months) observation) have been performed with Ceroxide and Barium. The concentrations chosen covered the range around and above the occupational exposure concentrations. Potential concentration-effect relationship can be made. Moreover, long-term inhalation toxicity data about carbon nanotubes are available. The workshop will give an overview of the most recent data on carcinogenicity of inhaled poorly soluble nanomaterials, as well as potential underlying mechanism for the effects. The session will also deal with potential genotoxicity and the kinetics of these nano materials.
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