LinkedInFacebook
back to homepage

Session 18

New approaches to skin sensitisation safety assessment

Programme of the Session

  • Progress in the validation and regulatory adoption of alternative approaches for skin sensitisation assessment 
    Silvia Casati 
    European Commission, Joint Research Centre, Ispra, Italy
  • Impact of Cutaneous Bioavailability in Local Skin Toxicity: Preliminary results from Cosmetics Europe Skin Bioavailability and Metabolism Task Force 
    Sebastien Gregoire1, Richard Cubberley2, Helene Duplan3, Joan Eilstein1, Corie Ellison4, Nicky Hewitt5, Carine Jacques-Jamin3, Daniela Lange6, Martina Klaric5, Helga Rothe7, Andreas Schepky6, Amy Roe
    1L'Oreal Research & Innovation, Aulnay sous Bois, France; 2Unilever, Sharnbrook, United Kingdom; 3Pierre Fabre Dermo-Cosmetique, Toulouse, France; 4Procter & Gamble Inc, Mason, United States; 5Cosmetics Europe, Brussels, Belgium; 6Beiersdorf AG, Hamburg, Germany; 7Coty, Darmstatd, Germany
  • Skin penetration in silico modeling-improvement by using in vitro data 
    Helga Rothe1,2, Sebastien Grégoire3, Cindy Obringer4, John Manwaring4, Joan Eilstein3, Daniela Lange5, Richard Cubberley6, Helen Duplan7, Carine Jacques-Jamin7, Corie Ellison4, Martina Klaric8, Nicky Hewitt8, Andreas Schepky5
    1Coty, Darmstadt, Germany; 2Procter and Gambel, Darmstadt, Germany; 3L'Oreal Research & Innovation, Aulnay-sous-Bois, France; 4)Procter & Gamble Inc, Mason, United States; 5)Beiersdorf, Hamburg, Germany; 6)Unilever, Bedford, United Kingdom; 7)Pierre Fabre Dermo-Cosmétique, Toulouse, France
    8)Cosmetics Europe, Brusells, Belgium
  • Cosmetics Europe’s skin sensitisation database 
    Sebastian Hoffmann1, Nathalie Alépée2, Takao Ashikaga3, Elodie Clouet4, Magalie Cluzel5, Aurelie Del Bufalo2, Nicola Gilmour6, Carsten Goebel7, Jalila Hibatallah8, Lauren Hutchison9, Petra Kern10, Jochen Kühnl11, Karsten Mewes12, Masaaki Miyazawa13, Erwin van Vliet14, Martina Klaric15, Dirk Petersohn12 
    1SEH consulting + services, Paderborn, Germany; 2L'Oréal, Paris, France; 3Shiseido, Kanagawa, Japan; 4Pierre Fabre, Toulouse, France; 5LVMH, St Jean de Braye, France; 6Unilever, Bradford, United Kingdom; 7Coty, Darmstadt, Germany; 8Chanel, Neuilly sur Seine, France; 9Colgate-Palmolive, Piscataway, United States; 10Procter & Gamble, Strombeeg-Bever, Belgium; 11Beiersdorf, Hamburg, Germany; 12Henkel, Düsseldorf, Germany; 13Kao, Tochigi, Japan; 14SeCAM, Magliaso, Switzerland; 15Cosmetics Europe, Brussels, Belgium
  • Skin sensitization testing strategy and safety assessment of topical ingredients: A case study 
    Dirk Petersohn1, Alépée Nathalie2, Takao Ashikaga3, Elodie Clouet4, Magalie Cluzel5, Aurelie Del Bufalo2, Nicola Gilmour6, Carsten Goebel7, Jalila Hibatallah8, Sebastian Hoffmann9, Lauren Hutchison10, Petra Kern11, Jochen Kuehnl12, Karsten Mewes1, Masaaki Miyazawa13, Erwin Van Vliet14, Martina Klaric15 
    1Henkel, Duesseldorf, Germany; 2L'Oréal, Paris, France; 3Shiseido, Kanagawa, Japan; 4Pierre Fabre, Toulouse, France; 5LVMH, St Jean de Braye, France; 6Unilever, Bedford, United Kingdom; 7Coty, Darmstadt, Germany; 8Chanel, Neuilly sur Seine, France; 9SEH Consulting Services, Paderborn, Germany; 10Colgate-Palmolive, Piscataway, United States; 11Procter & Gable, Strombeeg-Bever, Belgium; 12Beiersdorf, Hamburg, Germany; 13Kao, Tochigi, Japan; 14SeCAM, Services & Consultation on Alternative Methods, Magliaso, Switzerland; 15Cosmetics Europe, Brussels, Belgium

Session Abstract

The 7th Amendment to the Cosmetics Directive bans animal testing, therefore, the safety assessment of cosmetic ingredients has now to rely on the use of non-animal approaches.
This session provides an overview of projects run by the Cosmetics Europe Skin Bioavailability and Metabolism (Skin BM) Task Force (TF) and the Skin Tolerance (ST) TF. Results from these projects exemplify how safety assessment for skin sensitization and identification of possible systemic effects of topically applied chemicals can be performed in line with the 21st century vision for toxicity testing. The session will start with an illustration of the progress made in the development and regulatory adoption of non-animal methods for skin sensitization. The session will then delineate how data generated under the Skin BM project, using standardized dermal-based assays for a set of physicochemically diverse chemicals relevant to cosmetics and with potential dermal and/or systemic toxicity, can improve the predictivity of an in silico dermal penetration model. In addition it will be shown how bioavailability information (dermal absorption and metabolism) can be used in conjunction with readouts from skin sensitization in chemico and in vitro assays. Within the ST TF's project, a panel of non-animal skin sensitization methods have been evaluated and prioritised and data for more than 100 chemicals generated with the prioritised methods and incorporated into a database that will be made publically available in 2017. A case study will be presented to demonstrate how data from in vitro methods and in silico predictions can be integrated within defined approaches to testing and assessment and used together with exposure considerations to support risk assessment. Work undertaken by these Task Forces will ultimately lead to testing strategies that would enable cosmetic industries to conduct the safety assessment of cosmetic ingredients without the use of animals.
 
 
EUROTOXSETOX

© 2016–2017 GUARANT International