Toxicity of prescription opioids: improving knowledge to fight a worldwide threat
Programme of the Session
- Trends in opioid analgesic abuse and mortality in Europe in 2017
Rocky Mountain Poison & Drug Center, Denver Health & Hospital Authority, Denver, United States
- Opioid overdose: mechanisms of toxicity and variability of presentation
Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris-Diderot University, INSERM UMRS 1144, Paris, France
- Opioid education programs and nasal naloxone rescue kits in Europe
Arne Kristian Skulberg1,2, Ola Dale1, Ida Tylleskar1
1Department of circulation and medical imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; 2Department of Critical Care and Anaesthesiology, Oslo University Hospital, Oslo, Norway
New opioids to limit toxicity: where are we going?
Department of Chemistry, Vrije Universiteit Brussel, Brussels, Belgium
Prescription opioid abuse and misuse are a serious problem in the US; however, the situation in Europe is less clear, but recently collected data including by the GTNet international network are highly interesting. The increasing availability of maintenance treatments for heroin addiction represents another source of abuse. Experimental studies and clinical observations in human poisonings are able to identify possible mechanisms of toxicity, some of them being common to the different opioids and others specific of each marketed opioid molecule like codeine, methadone, buprenorphine and tramadol. To reduce opioid-related deaths, vast programs rendering naloxone kits available for bystanders are now developed in several European countries, like in the US. In addition, recent strategies to increase opioid-related antinociceptive properties and overcome major side-effects involve the creation of multifunctional compounds which contain hybridized structures (including the combination of opioids with other bioactive neurotransmitters and peptide hormones involved in pain perception) as well as the consideration of new route of administration. This workshop will review all these aspects of the epidemiology of opioid-related poisonings, their involved mechanisms of toxicity, the scientific research and the Governmental policies to reduce their resulting toxicity. Interaction with the public is important due to the highly debated issues.