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CEC 5

Nanotoxicology and risk assessment: the state of the art

Programme of the Session

  • Improving the OECD test guidelines to better address inhalation toxicity assessment of nanomaterials
    Ken Moss
    United States Environmental Protection Agency, United States
  • Principles and Methods for assessing the risk of immunotoxicity associated with exposure to nanomaterials: New WHO guidance
    Henk van Loveren
    Maastricht University, The Netherlands
  • Nanomaterials and cancer: what do we know? 
    Dawson Kenneth 
    School of Chemistry and Chemical Biology, Science Centre South, University College Dublin, Ireland
  • Availability of methods for characterising the physical-chemical properties of nanomaterials: implications for hazard identification, read-across and risk assessment 
    Juan Riego Sintes 
    Joint Research Centre of the European Union, Italy
  • Missing elements for regulatory testing and assessments of nanomaterials, and research needs
    Jenny Holmqvist
    ECHA - European Chemicals Agency, Finland

Session Abstract

There are growing concerns that exposure to nanoparticles may pose adverse health impacts, and that the adverse effects are greatly influenced by the small size and size-associated properties of nanoparticles. A decade of nanotoxicology research has clearly established that nanoparticles predominantly induce inflammatory response. Other effects may include adjuvant activity of allergic responses, neurological effects, reproduction effects, and genotoxicity resulting in carcinogenicity; some of these endpoints may in fact depend on inflammatory events occurring after exposure to nanoparticles.  This symposium aims to summarize the state of the art for risk assessment, and identify missing elements and research needs. 
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