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Clinical Toxicology: New insights in the mechanisms of toxicity mediated by metabolic pathways

Programme of the Session

  • 10:00 – 10:15 CE course opening and introduction
  • 10:15 – 10:55 Drug-induced liver injury: role of obesity and nonalcoholic fatty liver disease 
    Bernard Fromenty 
    INSERM, U991, Rennes-1 University, France
  • 10:55 – 11:35 Mechanisms of drug-induced lactic versus non-lactic endogenous acidosis 
    Bruno Mégarbane 
    Lariboisière Hospital, Paris-Diderot University, France
  • 11:35 – 12:00 Discussion
  • 12:00 – 13:00 Lunch
  • 13:00 – 13:40 Mechanisms of drug-induced hyperamonemia
    Florian Eyer
    Department of Toxicology, Klinikum rechts der Isar, Germany
  • 13:40 – 14:20 Mechanisms of drug-induced methemoglobinemia 
    Sally Bradberry
    Director of Poison Center West Midlands Poisons Unit, City Hospital, 
  • 14:20 – 15:00 Mechanisms of glycol-induced renal toxicity (including ethylene and di-ethylene glycol) 
    Ken McMartin 
    Louisiana State University Health Sciences Center - Shreveport Louisiana, USA
  • 15:00 – 15:40 Contribution of solvents in pesticide toxicity    
    Michael Eddleston
    NPIS Edinburgh, Royal Infirmary, UK
  • 15:40 – 16:00 Discussion and Closing of the CE course

Session Abstract

Investigating the mechanisms of toxicity in humans is helpful to understand the patterns and variability of presentations and to improve patient management. This Continuing Education Course aims to present the new insights in mechanisms of toxicity resulting from metabolic pathways as well as their relevance to clinical toxicology. Several metabolic impairments will be considered like non-lactic endogenous acidosis, hyperamonemia, methemoglobinemia, acute renal failure and liver injury. Recently published experimental data on acetaminophen, glycol and pesticide poisoning with high relevance to clinical toxicology will be presented.

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